ASCP hematology 해설 페이지
which of the following disorders has an increase in osmotic fragility?
Iron deficiency anemia
Hereditary elliptocytosis
Hereditary stomatocytosis
Hereditary spherocytosis
Spherocytic cells have decreased tolerance to swelling and, therefore hemolyze at higher concentration of sodium salt compared with normal red cells.
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Which of the following is not associated with
hereditary spherocytosis?
. Increased osmotic fragility
. An MCHC greater than 36%
. Intravascular hemolysis
Extravascular hemolysis
Classic features of intravascular hemolysis such as
hemoglobinemia, hemoglobinuria, or
hemosiderinuria do not occur in hereditary
spherocytosis. The hemolysis seen in hereditary
spherocytosis is an extravascular rather than an
intravascular process.
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